Synthetic Route of 14002-80-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C6H12O3, molecular weight is 132.16, as common compound, the synthetic route is as follows.
A solution of freshly distilled 25 sulfuryl chloride (3.3 mL, 45.4 mmol) in 26 Et2O (45 mL) was cooled to -78 C. under an atmosphere of Ar. A solution of 94 methyl 2,2-dimethyl-3-hydroxypropionate (3.0 g, 22.7 mmol) and 17 pyridine (2.2 mL, 27.2 mmol) in Et2O (20 mL) was added dropwise to the sulfuryl chloride solution over 30 min. The flask was rinsed with Et2O (3×5 mL) and the rinse was added to the reaction mixture. The mixture was stirred at -78 C. until completion (monitored by TLC, 30% EA/hex, 30 min). The precipitate was filtered, and the filtrate was concentrated under vacuum to afford 95 methyl 3-((chlorosulfonyl)oxy)-2,2-dimethylpropanoate(9a) (5.6 g, 70% yield). The mixture was stored at -78 C. and was used immediately for the next step without further purification. 1H-NMR (300 MHz, CDCl3) delta 4.50 (s, 2H), 3.74 (s, 3H), 1.31 (s, 6H).
Statistics shows that 14002-80-3 is playing an increasingly important role. we look forward to future research findings about Methyl 3-hydroxy-2,2-dimethylpropanoate.
Reference:
Patent; ARIXA PHARMACEUTICALS, INC.; GORDON, ERIC M.; DUNCTON, MATTHEW A.J.; FREUND, JOHN; (106 pag.)US2019/100516; (2019); A1;,
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