Reference of 2425-41-4 , The common heterocyclic compound, 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
20 g of 60 wt% NaH (Mw = 24 ? 0, 0.5 mol) were dispersed in 200 mL of dry tetrahydrofuran. 44.8 g of 2- ((2-phenyl) -1,3-dioxocyclohexyl) -1,3-propanediol (Mw = 224.25, 0.2 mol) were dissolved in 400 mL of dry tetrahydrofuran and suspended in NaH at room temperature Liquid, 25-30 C after the addition was continued for 2 hours. Cooled to 10 C, 42.6mol dimethyl sulfate (0.45mol) was added dropwise, after completion of the reaction was continued at room temperature for 4 hours, the reaction was refluxed for 4 hours. The reaction was stopped and 100 mL of water was added dropwise. The organic phase is washed twice with water, dried and filtered. The solvent was distilled off and the residue was distilled under reduced pressure to obtain about 46.3 g of product, yield 92%.
The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sinopec Corporation; Sinopec Corporation Beijing Chemical Institute; Zhou Qilong; Zhang Rui; Song Weiwei; Tan Zhong; Xu Xiudong; Yan Lian; Li Fengkui; Yu Jinhua; Yin Shanshan; (14 pag.)CN104591979; (2016); B;,
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