Related Products of 100058-61-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100058-61-5, name is 3-(Benzyloxy)cyclobutanol. A new synthetic method of this compound is introduced below.
To a solution of anti-3-(benzyloxy)cyclobutan-1-ol (3.65 mmol, 650 mg) in dry DMF (8 mL) was added 60% sodium hydride(5.47 mmol, 1.5 equiv.) portion wise at 0 C. After the mixture was stirred at 0 C for 15 min, iodomethane (7.29 mmol, 454 muL) was added dropwise at 0 C. The reaction mixture was stirred at room temperature (~ 25 C) for 1-2 h. The mixture was quenched with saturated aqueous of NH4Cl (10 mL), diluted with water (20 mL), extracted with ethyl acetate (20 mL × 2), washed with brine (20 mL), the organic layer was concentrated under reduced pressure, and the crude product was purified by column chromatography on silica gel (petroleum ether/ethyl acetate = 60:1 as eluent) to give ((anti-3-methoxycyclobutoxy) methyl) benzene (513 mg, 73 % yield) as colorless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100058-61-5, 3-(Benzyloxy)cyclobutanol, and friends who are interested can also refer to it.
Reference:
Article; Sheng, Ren; Yang, Liu; Zhang, Yanchun; Xing, Enming; Shi, Rui; Wen, Xiaoan; Wang, Heyao; Sun, Hongbin; Bioorganic and Medicinal Chemistry Letters; vol. 28; 15; (2018); p. 2599 – 2604;,
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