Adding a certain compound to certain chemical reactions, such as: 104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
EXAMPLE 125 Sulfamic acid 2-[4-[2-[(aminosulfonyl)oxy]ethoxy]phenoxy]ethyl ester A mixture of 19.8 g (0.1 mole) of hydroquinone bis (2-hydroxyethyl)ether (98%, Aldrich) and 41.4 g (0.41 mole) of triethylamine in 350 ml of acetonitrile was added to a cooled (acetone-ice bath, temp?15 C.) solution of 130 ml of sulfamoyl chloride solution (3.14 M solution in acetonitrile) and 100 ml of acetonitrile. The mixture was mechanically stirred at ambient temperature overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 400 ml of water and 800 ml of ethyl acetate. The aqueous layer was extracted with two 400 ml portions of ethyl acetate and the combined ethyl acetate extracts (1.61) were washed with two 400 ml portions of water, dried (magnesium sulfate) and the solvent evaporated under reduced pressure to give a viscous residue which was triturated with 100 ml of methylene chloride and let stand at ambient temperature for two days. The resulting solid was collected by filtration and then washed with water until the filtrate was neutral to pH paper and dried (air). The solid was recrystallized from acetonitrile to yield 9.9 g (29%) of a white solid containing a small amount of acetonitrile, mp 162-164 C. Analysis: Calculated for C10 H16 N2 O8 S2: C, 33.70; H, 4.53; N, 7.86. Found: C, 34.30; H, 4.62, N, 8.03.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, and friends who are interested can also refer to it.
Reference:
Patent; A. H. Robins Co., Inc.; US5025031; (1991); A;,
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