Application of 19064-18-7 ,Some common heterocyclic compound, 19064-18-7, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
15.5 ml (15.5 mmol) of a 1M solution of potassium tert-butoxide in tetrahydrofuran at 0 C was added to a solution of 1.72 ml (15.5 mmol) (2,6-difluorophenyl) methanol and 1.6 ml (15.5 mmol) 4-bromo-2-fluoropyridine in 50 ml of anhydrous tetrahydrofuran.The reaction mixture was stirred at room temperature for 18 h.It was partitioned between ethyl acetate and water.The organic phase was separated and washed with water and saturated aqueous sodium chloride solution, dried, filtered and concentrated over sodium sulfate.The residue was purified by chromatography on silica gel (40 g silica gel cartridge, mobile phase: cyclohexane / ethyl acetate, gradient 0% to 100%) purified.This gave 4.12 g of the target compound (88% d. Th.).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19064-18-7, (2,6-Difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
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