Reference of 3360-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3360-41-6, name is 4-Phenylbutan-1-ol. A new synthetic method of this compound is introduced below.
A CH2Cl2 solution (25 mL) of PPh3 (1.97 g,7.50 mmol) and I2 (1.90 g, 7.50 mmol) was stirred for 10 min at room temperature.Imidazole (851 mg, 12.5 mmol) was added to the resulting mixture. After a 10 min,4-phenylbutan-1-ol (751 mg, 5.00 mmol) was added to the mixture, and the resultingmixture was further stirred for 2 h. The mixture was quenched by the addition of satd.Na2S2O5 (25 mL). The aqueous and organic layers were separated, followed byextraction of the aqueous phase with CH2Cl2 (25 mL x 3). The combined organic phases were dried over anhydrous MgSO4, and the solvent was evaporated under reducedpressure. The crude product was purified by silica gel chromatography (eluent:hexane/AcOEt = 95/5) to give 4-iodobutylbenzene (1.14 g, 88%) as colorless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3360-41-6, 4-Phenylbutan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Sakai, Norio; Kobayashi, Taichi; Ogiwara, Yohei; Chemistry Letters; vol. 44; 11; (2015); p. 1503 – 1505;,
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