Electric Literature of 932-01-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 932-01-4, name is 4,4-Dimethylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.
Method A: To a solution of 4,4-dimethylcyclohexanol (100 mg, 0.78 mmol) and Et3N (201 mg, 1.56 mmol) in CH2C12 (2 mL) was added methanesulfonyl chloride (178 mg, 1.56 mmol) at 0C and the reaction mixture was stirred at rt for 2 h before it was quenched with water and was extracted with CH2C12. The organic layer was washed with brine, separated, dried, filtered and concentrated to afford 4,4-dimethylcyclohexyl methanesulfonate which was used without further purification. To a solution of 7-nitrophthalazin-l(2H)-one (Intermediate- 10, step-1 , 100 mg, 0.52 mmol) in THF (2 mL) was added NaH (41 mg, 1.02 mmol, 60% in mineral oil) at 0C and stirred for 15 minutes. Then a solution of 4,4-dimethylcyclohexyl methanesulfonate in THF (1 mL) was slowly added to the reaction mixture at 0C. Then the reaction mixture was heated at 80C for 6 h before it was quenched with water and was extracted with EtOAc. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 180 mg of the title product/H NMR (300 MHz, DMSO d6): delta 9.27 (s, 1H), 8.59-8.56 (d, / = 8.7 Hz, 1H), 8.30 (s, 1H), 7.88-7.85 (d, / = 8.7 Hz, 1H), 4.97-4.93 (m, 1H), 2.08-1.99 (m, 2H), 1.72-1.67 (m, 2H), 1.57-1.43 (m, 4H), 1.04 (s, 3H), 0.99 (s, 3H).
According to the analysis of related databases, 932-01-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2013/72825; (2013); A1;,
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