Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-70-8, name is 2-Amino-2-ethylpropane-1,3-diol. A new synthetic method of this compound is introduced below., COA of Formula: C5H13NO2
(19-1) Synthesis of [1,1-bis(hydroxymethyl)propyl]carbamic acid t-butyl ester (compound 19-1) To a solution of 2-amino-2-ethyl-1,3-propanediol (22.0 g) in methanol (500 ml) and N,N-diisopropylethylamine (64.3 ml) was added di-t-butyl dicarbonate (60.5 g) under ice-cooling, and the mixture was stirred for 40 min under ice-cooling and further at room temperature for 16 hr. 1M aqueous sodium hydroxide solution (184 ml) was added to the reaction mixture under ice-cooling and the mixture was stirred for 40 min. Methanol was removed under reduced pressure. Water was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (41.0 g) as a colorless oil. 1H-NMR(CDCl3)delta(ppm): 0.90(3H, t, J=7.5Hz), 1.45(9H, s), 1.59(2H, q, J=7.5Hz), 3.45(2H, brs), 3.60(2H, dd, J=6.9, 11.6Hz), 3.84(2H, dd, J=4.8, 11.6Hz), 4.89(1H, brs).
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Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1961734; (2008); A1;,
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