Application of 6338-55-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6338-55-2 as follows.
To a 1 L three-necked flask, 23.5 g of a compound BP103a03 (1.0 eq), 68.6 g (Boc)2O (2.0 eq), and a mixture of methanol and triethylamine (9:1) (500 ml) were added, and the mixture was stirred and refluxed for 1 h. After completion of the reaction was monitored by TLC, methanol was evaporated triethylamine, dissolved in water and extracted three times with dichloromethane, and the combined organic layers were washed with water once, dried over anhydrous sodium sulfate, the solvent was distilled off, and dried to give a solid BP103a04 of 34.8g
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.
Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Huang Yangqing; Song Yunsong; (20 pag.)CN109771658; (2019); A;,
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