Synthetic Route of 1462-03-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1462-03-9, name is 1-Methylcyclopentanol. A new synthetic method of this compound is introduced below.
E11-1 : Potassium cyanide (1. 43 g, 22.0 mmol) was added to a stirred solution of METHYLCYCLOPENTANOL (2.00 g, 20.0 MMOL) in glacial acetic acid (1.00 mL) resulting in a thick slurry. To this was added, dropwise, sulfuric acid (3 mL, caution: exothermic) at a rate at which the temperature was maintained at ca. 30-35C. Additional acetic acid (1 mL) was added to facilitate stirring of the thick paste. The mixture was then heated to 55-60C for 30 min followed by stirring at ambient temperature for 16 h. Ice cold water (35 mL) was then added, the mixture extracted with ethyl ether (2x 40 mL) and the combined organic phases washed with 5% NAHCO3 (5x 30 mL), dried over MGS04 and the solvent evaporated to yield a pale brown oil (1.16 g). The pH of the combined aqueous washings was then raised to pH 11 by the addition of solid K2CO3 AND the resulting solids filtered and washed with ethyl ether (3x 40 mL). The filtrate was extracted with ethyl ether (2x 40 mL), the combined extracts dried over MgS04 and the solvent evaporated to yield additional product (0.355 g) which was combined with the above obtained oil (1.52 g, 60 %).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1462-03-9, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO KG; WO2004/103996; (2004); A1;,
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