Related Products of 5299-60-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of donor (1 mmol) in dry CH2Cl2 (5-10 ml) was added under argon ethyl 6-hydroxy-hexanoate (1.5 mmol) and 4 A molecular sieves (mass = donor + acceptor weight) then the mixture was stirred for 15 min. N-Iodosuccinimide (3 mmol) and trifluoromethanesulfonic acid (0.3 mmol) were successively added and after stirring 30 min at room temperature, the mixture was diluted with CH2Cl2, filtered on a celite pad and washed with satd aq NaHCO3 and satd aq Na2S2O3. The aqueous layer was extracted with CH2Cl2 then the combined organic layers were dried (MgSO4), filtered and concentrated. The residue was purified by flash chromatography.
According to the analysis of related databases, 5299-60-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Despras, Guillaume; Robert, Raymond; Sendid, Boualem; MacHez, Emeline; Poulain, Daniel; Mallet, Jean-Maurice; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1817 – 1831;,
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