Related Products of 769-30-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. A new synthetic method of this compound is introduced below.
To a solution of 4-hydroxymethyl-benzo[1 ,3]dioxole (1.00 g, 6.6 mmol) and carbon tetrabromide (3.50 g, 10.5 mmol) in anhydrous tetrahydrofuran (30 ml.) was added at 00C triphenylphosphine (2.80 g, 10.5 mmol) in solution in tetrahydrofuran (10 mL). The resulting reaction mixture was stirred at room temperature for 2 hours. Water (30 mL) was added followed by ethyl acetate (30 mL). The organic layer was washed first with a concentrated aqueous sodium hydrogenocarbonate solution (30 mL) and then brine (30 mL), dried over anhydrous potassium carbonate and concentrated in vacuum. The resulting crude product was purified by flash chromatography on silica gel, eluting with cyclohexane – dichloromethane (7:3) to afford the title compound (1.23 g, 87%) as colorless oil.[00694] 1H NMR (CDCI3): delta 6.86 – 6.75 (m, 3H), 6.02 (s, 2H), 4.47 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, and friends who are interested can also refer to it.
Reference:
Patent; NPS PHARMACEUTICALS, INC.; WO2007/44796; (2007); A2;,
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