Electric Literature of 454-91-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. This compound has unique chemical properties. The synthetic route is as follows.
4-(2-Fluorophenyl)-2-methyl-2H-pyrazol-3-amine (150 mg, 0.78 mmol) and triphosgene (303 mg, 1.02 mmol) were dissolved in dichloromethane (3 mL). Toluene (8 mL) was added and the mixture was sealed. The mixture was stirred in an ice bath and TEA (0.9 mL, 8.0 eq) was added. The mixture was stirred at 85 C for 20 minutes and l-(3-(trifluoromethyl)-phenyl)ethanol (194 mg, 1.02 mmol) in toluene (2 mL) was added. The mixture was stirred at 90 C for 2 fir. Solvents were evaporated and the residue was extracted with ethyl acetate and water. The organic layer was washed with brine and dried. Solvents were evaporated and the residue was purified by ISCO flash column chromatography (0% to 60% ethyl acetate in hexanes) to give [4-(2-fluoro- phenyl)-2-methyl-2H-pyrazol-3-yl]-carbamic acid l-(3-trifluoromethyl-phenyl)-ethyl ester as a pale yellow waxy material (226 mg, 70.7% yield). 1H-NMR (400 MHz, DMSO-de) delta ppm 1.11- 1.29 (m, 0.6H), 1.55 (br d, J=5.81 Hz, 2.4H), 3.65 (s, 3H), 5.73-5.85 (m, 1H), 7.06-7.24 (m, 2H), 7.25-7.52 (m, 3H), 7.56-7.82 (m, 4H), 9.29 (br s, 0.2H), 9.66 (s, 0.8H); LC/MS calcd for C2oHi7F4N302 (m/e) 407.0, obsd 408.0 (M+H, ES+)..
According to the analysis of related databases, 454-91-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189862; (2013); A1;,
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