Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7
Example 10-A. (±)-Methyl 2-(2-((6-bromo-2,3-dihydro-1 H-inden-1 -yl)oxy)phenyl)acetate DIAD (1 .165 mL, 5.99 mmol) was added dropwise to a solution of PPh3 (1 .571 g, 5.99 mmol), 6-bromo-2,3-dihydro-1 H-inden-1 -ol (CAS 75476-86-7) (1 .1 1 g, 5.21 mmol) and methyl 2-(2-hydroxyphenyl)acetate (0.996 g, 5.99 mmol) in THF (1 5 mL) at 0 C. The reaction mixture was allowed to stir for 15 minutes at 0 C and then warmed to room temperature. The reaction mixture was stirred at room temperature overnight, partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc . The combined organics were washed with brine, dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography (30% EtOAc- heptane) tor provide the title compound. MS (ESI ) m/z 359.0, 361 .0 (M-H)~.
The synthetic route of 75476-86-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BELANGER, David; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; KARKI, Rajeshri Ganesh; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; MAINOLFI, Nello; POWERS, James J.; VULPETTI, Anna; (100 pag.)WO2016/88082; (2016); A1;,
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