Application of 1124-63-6 ,Some common heterocyclic compound, 1124-63-6, molecular formula is C9H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
3-Cyclohexylpropanal To a solution of commercially available 3-cyclohexylpropanol (45.5 g, 0.32 mol) in CH2C12 (1000 mL) was added PCC (103.5 g, 0.48 mol), Celite 545 (50 g) and stirred at room temperature for 3 h. The reaction mixture was diluted with ethyl ether (1000 mL), stirred at rt for 1 h, before it was filtered through Celite and silica gel (1 : 1) pad. The filtrate was concentrated to give crude residue. Crude product was purified by silica gel flash chromatography (0-30% EtOAc/hexanes) to give the title compound as oil (50.7 g), which contained residual hexanes as judged by NMR analysis. lH NMR (300 MHz, CDCb) delta 0.83 – 0.98 (m, 3 H), 1.15 – 1.31 (m, 4 H), 1.49 – 1.56 (m, 2 H), 1.61 – 1.73 (m, 4 H), 2.41 – 2.46 (m, 2 H), 9.77 (s, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1124-63-6, its application will become more common.
Reference:
Patent; RESEARCH TRIANGLE INSTITUTE; RUNYON, Scott, P.; MAITRA, Rangan; NARAYANAN, Sanju; THOMAS, James, Barnwell; REHDER, Kenneth, S.; OLEPU, Srinivas; (194 pag.)WO2017/100558; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts