Application of 30595-79-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 3: To a solution of 2-(2,6-dichlorophenyl)ethanol (37.3 g, 195 mmol) and TEA (32.7 g, 235 mmol) in DCM (700 mL) was added MsCI (26.9 g, 235 mmol) dropwise at 0C. After addition, the solution was stirred at rt overnight, diluted with water (200 mL) and extracted with DCM (3 x 400 mL). The combined organic layer was dried over Na2S04, filtered, concentrated and purified by flash chromatography (PE/EtOAc = 5:1 ) to afford 2,6-dichlorophenethyl methanesulfonate lnt-1 c- 11. 1H-NMPi (300 MHz, CDCI3): delta 2.95 (s, 3H), 3.43 (t, J = 7.5 Hz, 2H), 4.41 (t, J = 7.5 Hz, 2H), 7.12-7.17 (m, 1 H), 7.31 (d, J = 8.4 Hz, 2H)
According to the analysis of related databases, 30595-79-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; SCHMITT, Aaron C.; GEGE, Christian; (205 pag.)WO2016/96115; (2016); A1;,
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