With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, molecular formula is C9H11ClO, molecular weight is 170.64, as common compound, the synthetic route is as follows.HPLC of Formula: C9H11ClO
General procedure: In a typical procedure, isopropenyl acetate (1.5 equiv.) was added to a 4 mL-vial containing BSLPL-1c-D (3 mg), substrate (0.3 mmol), and anhydrous toluene (0.5 M). The resulting solution was then shaken at 25 C until the reaction reached 46-50% conversion. After being diluted with methylene chloride, the reaction mixture was filtered through a celite pad, concentrated, and then analyzed by HPLC to determine the enantiomeric excesses of remaining substrate and acetylated product. The enantioselectivity (E) was then calculated using the equation: E = ln[1-c(1+eep)]/ln[1-c(1-eep)] where c = ees/(ees+eep). The kinetic resolution of 4a: (S)-4a (82%ee) and (R)-5a (97% ee); 46% conversion; E = >100. The kinetic resolution of 4b: (S)-4b (>99%ee) and (R)-5b (97% ee); 50% conversion; E=>100.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18776-12-0, 3-Chloro-1-phenylpropan-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Oh, Yeonock; Choi, Yoon Kyung; Yun, Inyeol; Lee, Eungyeong; Kim, Kyungwoo; Kim, Mahn-Joo; Journal of Molecular Catalysis B: Enzymatic; vol. 134; (2016); p. 148 – 153;,
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