Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(3-Fluorophenyl)ethanol
A mixture of 2-(3-fluorophenyl)ethanol (0.052 mL, 0.419 mmol), NaH (0.017 g, 0.419 mmol), and (S)-isopropyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?- difluoro-6-methyl-[3,3?-bipyridinj-5-yl)acetate (0.041 g, 0.084 mmol) in THF was stirred at ambient temperature for 1 h. Then, 5 M NaOH (0.167 mL, 0.837 mmol) was added andthe mixture was heated at 80 C for 2 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (23.4 mg, 49%). ?H NMR (500 MHz, DMSO-d6) 8.14 – 8.03 (m, 1H), 7.93 (d,J= 1.8Hz, 1H),7.70(dd,J 11.0, 1.8Hz, 1H),7.42-7.24(m, 1H),7.21 -6.97(m, 3H), 5.83 (s, 1H), 4.67 (t, J= 6.6 Hz, 2H), 3.18 -3.00 (m, 1H), 1.32 (br s, 3H), 1.14 (s, 1OH), 0.89 – 0.76 (m, 6H) [note: piper/dine protons not all visiblej. LCMS (M+1) =568.3.
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Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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