Related Products of 530-91-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, molecular weight is 148.2017, as common compound, the synthetic route is as follows.
EXAMPLE 81 To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol (318 mg), 2-hydroxytetralin (296 mg), tributylphosphine (405 mg) and tetrahydrofuran (10 ml) was added 1,1′-(azodicarbonyl)dipiperidine (400 mg) at room temperature, and the resulting mixture was stirred for 1 hour. After the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography, and 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(5,6,7,8-tetrahydro-2-naphthoxy)propyl]oxazole was obtained as an oil from an ethyl acetate-hexane (1:1, v/v)-eluted fraction. (358 mg, 80%).
Statistics shows that 530-91-6 is playing an increasingly important role. we look forward to future research findings about 1,2,3,4-Tetrahydronaphthalen-2-ol.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6605629; (2003); B1;,
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