Related Products of 4152-92-5, Adding some certain compound to certain chemical reactions, such as: 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-92-5.
A solution of 1.7 g of 2-(aminomethyl)benzyl alcohol (12. 4 mmol) and 1.76 mL of triethylamine (12. 4 mmol) was dissolved in 20 mL anhydrous methanol, 1.96 mL of ethyl trifluoroacetate (16.4 mmol) was added dropwise under argon and the reaction was stirred at 25 C for 2 hours. After the reaction, ethyl acetate (30 mL) and water (30 mL) were added to the extract. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate overnight, and the solvent was removed in vacuo to give 2-[(trifluoroacetamido)methyl]benzyl alcohol. The crude product was purified by silica gel column chromatography eluting with ethyl acetate / cyclohexane (1: 2, v / v) to give 2-[(trifluoroacetamido)methyl]benzyl alcohol (2.0 g, 8.6 mmol), 69% yield.
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Reference:
Patent; Beijing University of Technology; Zhao, Lijiao; Sun, Guohui; Zhong, RuGang; (20 pag.)CN104031048; (2016); B;,
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