Synthetic Route of 2050-25-1, Adding some certain compound to certain chemical reactions, such as: 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol,molecular formula is C11H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2050-25-1.
tert-Butyl 2 – (2 – (2 – (benzyloxy) ethoxy) ethoxy) acetate KOtBu (20 mL, 20 mmol) was added to a stirred solution of 2-(2-(benzyloxy)ethoxy)ethanol (commercially available from for example Aldrich) (2.74 mL, 15 mmol) in tBuOH (30 mL) and the mixture was stirred under a nitrogen atmosphere at room temperature for 2 hours. The reaction mixture was cooled to 0C, tert-butyl 2-bromoacetate (commercially available from for example Aldrich) (4 mL, 28 mmol) was added and the mixture stirred at room temperature overnight. The reaction mixture was then concentrated, and partitioned between water (50 mL) and DCM (50 mL). The organic layer was separated and the aqueous layer was extracted further with DCM (50 mL). The combined organic layers were dried using a hydrophobic frit and concentrated under reduced pressure. The product was purified by chromatography on silica using a gradient elution from 0 % to 100 % methyl tert-butyl ether in cyclohexane to afford the title compound (3.56 g, 11 mmol, 74% yield). LCMS RT= 1.11 min, ES+ve m/z 311.4 [M+H]+, 328.4 [M+NH4] +.
According to the analysis of related databases, 2050-25-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMPOS, Sebastien, Andre; HARLING, John, David; MIAH, Afjal, Hussain; SMITH, Ian, Edward, David; WO2015/867; (2015); A1;,
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