Related Products of 3360-41-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3360-41-6, name is 4-Phenylbutan-1-ol, molecular formula is C10H14O, molecular weight is 150.22, as common compound, the synthetic route is as follows.
The title compound can be prepared in a three-step process based on publication by Rong and Ruoho (1999). First, the alkoxide generated with NaH from 4-phenylbutanol can be alkylated with 1, 6-dibromohexane in presence of catalytic tetrabutylammonium bromide. The thus obtained bromide can be substituted by heating with sodium azide and catalytic sodium iodide in DMSO at 80C. The azide can then be reduced by hydrogenation in presence of palladium catalyst and di-t-butyl dicarbonate, obtaining the desired Boc-protected amine 23.
The chemical industry reduces the impact on the environment during synthesis 3360-41-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; CORUS PHARMA; WO2005/63777; (2005); A1;,
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