As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-(Allyloxy)ethanol
30.6 g (0.3 mol) of allyloxyethanol was dissolved in 100 ml of methylene chloride,Further, a solution prepared by adding 33.4 g (0.33 mol) of triethylamine and 1.8 g (0.015 mol) of N, N-dimethylaminopyridine was prepared.next,The obtained solution was cooled with ice,To this solution,A solution of 31.4 g (0.3 mol) of methacrylic acid chloride in 50 ml of methylene chloride was added dropwise.After completion of the dropwise addition,After stirring at room temperature for 3 hours,100 ml of distilled water was added,It was extracted three times with methylene chloride.Next, the obtained methylene chloride layer was removed using a rotary evaporator to remove the solvent, and the residue obtained was dissolved in 100 ml of toluene to obtain a toluene solution.Then, this toluene solution was washed three times with 0.5 N hydrochloric acid solution,Washed three times with saturated saline solution,And dried with magnesium sulfate solution.After drying, the magnesium sulfate solution was filtered off,The filtrate was concentrated on a rotary evaporator to obtain a concentrate.further,The concentrate was vacuum dried,Methacrylic acid-allyloxyethyl 46.0 g (yield 90%).
With the rapid development of chemical substances, we look forward to future research findings about 111-45-5.
Reference:
Patent; TOKUYAMA DENTAL CORPORATION; AKIZUMI, HIRONOBU; SAKATA, EIBU; (52 pag.)JP2017/141212; (2017); A;,
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