Related Products of 140373-17-7 , The common heterocyclic compound, 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 47: Preparation of 2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-(4-fluoro- phenyl)-ethanol Under an Ar atmosphere, a mixture of 2-chloro-6-(3-chloro-phenyl)-pyrazine (112.5 mg, 0.5 mmol) and 2-amino-2-(4-fluoro-phenyl)-ethanol (230 mg, 1.5 mmol) was exposed to microwave irradiation at 180 C for 1 hour. After the reaction was completed as monitored by LC-MS, the residue was partitioned between EtOAc and brine. The aqueous layer was separated and then extracted with EtOAc. The combined organic layers were concentrated, and then the residue was purified by Prep-HPLC to give 2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-(4- fluoro-phenyl)-ethanol (10 mg).
The synthetic route of 140373-17-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; WANG, Jianhua; WANG, Min; YANG, Song; ZHOU, Chengang; WO2014/106606; (2014); A1;,
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