Synthetic Route of 599-67-7 ,Some common heterocyclic compound, 599-67-7, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of 1 (2 mmol), 2 (4 or 15 mmol) and NaHSO4/SiO2 (2.1 mmol/g, 1.0 or 2.0g) in DCE (10 mL) was stirred at 80 C for 2 h, and then the used supported reagent was removed by filtration. The filtrate was evaporated to leave crude product, which was purified by column chromatography (hexane/chloroform) to obtain substituted chromans 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.
Reference:
Article; Aoyama, Tadashi; Furukawa, Takuya; Hayakawa, Mamiko; Takido, Toshio; Kodomari, Mitsuo; Synlett; vol. 26; 13; (2015); p. 1875 – 1879;,
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