Reference of 623-69-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.
Section 1 step: the epoxychloropropane and methanol under the action of the NaOH, in order to an excess of methanol as a solvent reflux reaction 6 hours, to obtain 1,3-dimethoxy-2-propanol; The mole ratio is that, epoxychloropropane: NaOH= 1 : 1.05; Methanol consumption per mole of epichlohydrin substrate for adding 0.6L of the methanol. Section 2 step: the resulting 1,3-dimethoxy-2-propanol with 4-n-butyl benzoyl chloride in triethylamine under the action of acid, in tetrahydrofuran solvent reflux reaction for 7 hours, shown in formula III obtained ether acid ester composition (i); The mole ratio is that, 1,3-dimethoxy-2-propanol: 4-n-butyl benzoyl chloride: triethylamine = 1:1: 1.5; Tetrahydrofuran according to the amount of per mole of the 1,3-dimethoxy-2-propanol is added to substrate 1.5L tetrahydrofuran
Statistics shows that 623-69-8 is playing an increasingly important role. we look forward to future research findings about 1,3-Dimethoxypropan-2-ol.
Reference:
Patent; China Petroleum and Chemical Corporation; China Petroleum & Chemical Corporation Beijing Research Institute of Chemical; Hu, Jianjun; Liu, Haitao; Gao, Mingzhi; Ma, Jixing; Cai, Xiaoxia; Zhang, Xiaofan; Chen, Jianhua; Ma, jing; Li, Changxiu; Li, Xianzhong; Wang, Jun; (12 pag.)CN103664615; (2016); B;,
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