Reference of 50411-26-2, Adding some certain compound to certain chemical reactions, such as: 50411-26-2, name is 1-Amino-3-phenylpropan-2-ol,molecular formula is C9H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50411-26-2.
To a stirring solution of 1-amino-3-phenyl-propan-2-ol (0.51 g, 3.3 mmol) and triethylamine (0.45 mL, 3.3 mmol) in 20 mL dichloromethane was added (0.92 g, 2.6 mmol) 2-chloro-3-methyl-5-naphthalen-2-yl-6-pyridin-4-yl-3H-pyrimidin-4-one. The solution was stirred for 18 h at room temperature. The solution was diluted with ethyl acetate and washed with 5% sodium bicarbonate. The organic layer was dried over magnesium sulfate and purified on 10 g silica eluting product with 0 to 5% methanol/dichloromethane to give a pale yellow solid. M+1=463.2.
According to the analysis of related databases, 50411-26-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Amgen Inc.; US2005/43301; (2005); A1;,
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