As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450754-41-2, name is 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, molecular formula is C7H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol
(f) imidazole (740 mg, 10.87 mmol, 3.0 eq),Triphenylphosphine (1.05 g, 3.99 mmol, 1.1 eq)Add dichloromethane (5ml) to the reaction flask and cool to 0 C.Add iodine (1.1 g, 4.35 mmol, 1.2 eq),Add the insulation reaction for 30 minutes.Add compound 5 (500 mg, 3.62 mmol, 1 eq) at low temperatureA solution of methylene chloride (1 ml) was added and the reaction was kept for 4 hours.Quenched with saturated sodium sulfite solution, extracted with ethyl acetate.Dry, spin dry, and purified by column to obtain 400 mg of compound 6,Yield: 46%
With the rapid development of chemical substances, we look forward to future research findings about 1450754-41-2.
Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (7 pag.)CN109438211; (2019); A;,
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