Electric Literature of 41790-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41790-30-1, name is (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol, molecular formula is C11H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2 – Tetralin-5-carbaldehyde (0543) [00350] To a solution of tetralin-5-ylmethanol (7.20 g, 44.3 mmol) in dichloromethane (100 mL) was added manganese dioxide (19.2 g, 221 mmol) under a nitrogen atmosphere. The mixture was stirred at 20 C for 6 hrs. On completion, the mixture was filtered; the filtrate was concentrated in vacuo to afford a residue. The residue was purified with silica gel chromatography (petroleum ether:ethyl acetate = 20:1) to afford the title compound. 1H NMR (400MHz, DMSO-d6) delta = 10.23 (s, 1H), 7.65 (dd, J = 1.1, 7.4 Hz, 1H), 7.41 – 7.35 (m, 1H), 7.35 – 7.29 (m, 1H), 3.15 (t, J = 6.1 Hz, 2H), 2.79 (t, J = 6.0 Hz, 2H), 1.79 – 1.69 (m, 4H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41790-30-1, (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel P.; SAIAH, Eddine; (264 pag.)WO2017/156181; (2017); A1;,
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