Electric Literature of 29908-11-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29908-11-0, name is (1,4-Dioxan-2-yl)methanol. A new synthetic method of this compound is introduced below.
To a solution of(l, 4-dioxan-2-yl) methanol (2.4 g) in dimethylsulfoxide (24 mL) was added 5-bromo-2-chloropyridine (3.91 g) and sodium hydride (0.81 g) at 20 C under nitrogen flow. Thereaction mixture was stirred at 60 C for 10 hours under nitrogen atmosphere. The reaction was diluted with water (40 mL) at 25 C and extracted with ethyl acetate (3 x 40 mL). The combined organic layers were washed with brine (5 x 20 mL) and dried over sodium sulfate. After filtration, the filtrate was concentrated to give a residue which was purified by colunm chromatography on silica gel (eluted with petroleum ether:ethyl acetate = 100:1 to 20:1) to give the title compound. ?H NMR (400 MHz, CDC13) 6ppm 8.15 (d, 1H), 7.63 (dd, 1H), 6.70 (d, 111) 4.38-4.49 (m, 2H), 3.78-3.85 (m, 2H), 3.59-3.71 (m, 6H),3.52 (dd, 2H), 3.35 (s, 311).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29908-11-0, its application will become more common.
Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; BRAJE, Wilfried; DOHERTY, George; JANTOS, Katja; JI, Cheng; JUDD, Andrew; KUNZER, Aaron; MASTRACCHIO, Anthony; SONG, Xiaohong; SOUERS, Andrew; SULLIVAN, Gerard; TAO, Zhi-Fu; TESKE, Jesse; WANG, Xilu; WENDT, Michael; PENNING, Thomas; LAI, Chunqui; KLING, Andreas; POHLKI, Frauke; (197 pag.)WO2019/35911; (2019); A1;,
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