Related Products of 14593-04-5 , The common heterocyclic compound, 14593-04-5, name is 3-Amino-3-phenyl-1-propanol, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
a 4-Chloro-2-[(3-Hydroxy-1-Phenylpropyl)Amino]Benzonitrile A mixture of 3-amino-3-phenylpropanol (1 g, 6.6 mmol) and 4-chloro-2-fluorobenzonitrile (1 g, 6.4 mmol) in diisopropylethylamine (1.2 ml, 6.9 mmol) was heated at 140¡ã C. for 5 h. The crude reaction mixture was cooled to room temperature and applied to a silica column. The title compound was isolated as a colourless solid (1.1 g, 58percent) by elution with 20percent diethyl ether/isohexane. MS APCI+vem/z287 ([M+H]+).
The synthetic route of 14593-04-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cheshire, David; Connolly, Stephen; Cox, David; Millichip, Ian; US2003/73685; (2003); A1;,
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