A new synthetic route of 18776-12-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. name: 3-Chloro-1-phenylpropan-1-ol

Example 4145To a stirred solution of 3-chloro-i-phenyl-i-propanol (1.1 mmol) in dry DCM is added imidazole (2.33. mmol) followed by DMAP (0.11 mmol) and stirred for 1Z. h. Then TBDMSCI 4.68 mmol) is added and stirred for 12 h at rt and reaction is monitored by TLC. The reaction mixture diluted with water and extracted with DCM (3 x 30 mL) and washed with plain water, brine and dried (over with and concentrated under vacuum below 40 0C using rotavapour. MS: M+ 284.9

The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; US DEPARTMENT OF HEALTH & HUMAN SERVICES; WO2007/75872; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts