Related Products of 4152-92-5 , The common heterocyclic compound, 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
An ice-cold pyridine solution (10 mL) of compound 23 (1 mmol) is treated successively, in a dropwise fashion with acetyl chloride (1 mmol), then after 5 min with MsCl (1.1 mmol). The solution is warmed to room temperature then the solvent is removed. The residue is dissolved in EtOAc, washed with water, dried (MgS04), filtered and concentrated in vacuo. Purification by column chromatography affords pure compound 24.
The synthetic route of 4152-92-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ONTORII, INC.; BUTLER, David; IWAMOTO, Naoki; MEENA, Meena; SVRZIKAPA, Nenad; VERDINE, Gregory L.; ZLATEV, Ivan; WO2014/12081; (2014); A2;,
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