Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Amino-1,1,1-trifluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 3-Amino-1,1,1-trifluoropropan-2-ol
General procedure: To a stirred solution of amino alcohol 5 (8.80 mmol, 1.10 equiv.) in DMF (16.0 mL, 0.5M) atroom temperature was added isothiocyanate 4 (8.00 mmol, 1.00 equiv.). After stirring for 2minutes at room temperature, Vilsmeier salt 3 (12.00 mmol, 1.50 equiv.) and iPr2NEt (12.00mmol, 1.50 equiv.) were added sequentially. The reaction mixture was allowed to stir at 75Cuntil adjudged complete by TLC, generally 4 hours. The reaction was diluted with EtOAc(50mL) and sequentially washed with sat. aq. NaHCO3 (25mL) and brine (25mL). The organiclayer was dried over MgSO4, polish filtered, and concentrated under reduced pressure. The cruderesidue was purified by silica gel column chromatography (100% heptane to 80% EtOAc inheptane gradient) to give 6.
The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Corbett, Michael T.; Caille, Seb; Synlett; vol. 28; 20; (2017); p. 2845 – 2850;,
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