Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-01-4, name is 4,4-Dimethylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. 932-01-4
To a mixture of 4,4-Dimethylcyclohexanol (63.2 mg, 0.000493 mol), (R)-4-(6- hydroxynaphthalen-2-yl)-4-methyl-oxazolidin-2-one (100 mg, 0.0004 mol), 5 triphenylphosphine (129 mg, 0.000493 mol), and tetrahydrofuran (4 mL, 0.05 mol), diisopropyl azodicarboxylate (0.0971 mL, 0.000493 mol ) was added dropwise and was stirred at room temperature overnight. The mixture was diluted with EA and washed with 5% citric acid and brine then dried with magnesium sulfate and concentrated. The crude was taken up into DCM and subjected to ISCO combiflash purification with EtOAc/hexane (0- I0 70) to give product.
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Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine; WO2010/51030; (2010); A1;,
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