2050-25-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-(2-Benzyloxyethoxy)ethanol [44] (1, 12.96 g, 66 mmol) and succinic acid anhydride (8.12 g, 81.1 mmol) were dissolved in CH2Cl2 (200 ml), and DMAP (9.95 g, 81.4 mmol) was added. The solution was stirred at ambient temperature for 1 h. Then AcOH (1 ml) was added and the mixture was evaporated under reduced pressure. The crude product was purified by gradient Fc (toluene/AcOEt/AcOH 150:50:2 to 25:75:1). This provided an oily liquid. Yield: 10 g (51%). 1H NMR (250 MHz, CDCl3), delta: 2.64 (s, 4H, COCH2CH2CO), 3.60-3.72 (m, 6H, PhCH2OCH2CH2OCH2CH2), 4.22-4.30 (m, 2H, CH2CH2OCO), 4.57 (s, 2H, PhCH2O), 7.30-7.37 (m, 5H, Ph), 10.53 (s, 1H, COOH). 13C NMR (62.5 MHz, CDCl3), delta: 29.0, 29.0, 63.9, 69.1, 69.4, 70.6, 73.3, 127.7, 127.9, 128.4, 138.1, 172.2 (COOR), 177.3 (COOH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2050-25-1, 2-(2-(Benzyloxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Coufalova, Lenka; Mrozek, Lech; Rarova, Lucie; Pla?ek, Luka?; Opat?ilova, Radka; Dohnal, Ji?i; Kral’Ova, Katarina; Paleta, Old?ich; Kral, Vladimir; Dra?ar, Pavel; Jampilek, Josef; Steroids; vol. 78; 5; (2013); p. 435 – 453;,
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