Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. 55414-72-7
Potassium tert-butoxide (49.3 mg, 0.439 mmol) was dissolved in technical-grade THF(1.7 mL, containing ~0.2% H2O), and the solution was stirred at room temperature in air for 1 min.A solution of amide 6 (51.2 mg, 0.245 mmol) and 2-amino-5-methoxybenzyl alcohol (43.3 mg,0.283 mmol) in THF (0.8 mL) was added, and the mixture was stirred at room temperature in air for3 h. Water (20 mL) was added, and the mixture was extracted with ethyl acetate (20 mL). Theorganic layer was washed with 1M aqueous HCl solution (3 ¡Á 20 mL). The organic layer was driedover MgSO4, filtered, and concentrated in vacuo. The crude product was purified by flashchromatography using 1:2 ethyl acetate / dichloromethane as eluent to give the title compound as awhite solid (13 mg, 17%).
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Reference:
Article; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Lizarme, Yuvixza; Morris, Jonathan C.; Hunter, Luke; Synlett; vol. 27; 8; (2016); p. 1237 – 1240;,
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