Application of 2566-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.
Take a single-necked flask and add 2-cyclopropylethanol (2.4g, 28mmol), DMF (30mL) in sequence, cool to 0 C, add sodium hydrogen (1.3g, 33mmol, 60% by mass), and stir the reaction mixture at room temperature for 20min Add 3- (benzyloxy) 2-bromo-6-iodopyridine (10g, 25.6mmol), heat to 100 C and continue stirring for 12h.Post-treatment: add water (50 mL) to quench the reaction, extract with ethyl acetate (20 mL × 3), combine the organic phases, wash the organic phase with saturated brine (50 mL × 3), dry over anhydrous sodium sulfate, filter, and concentrate under reduced pressure The filtrate and the residue were separated by silica gel column chromatography (PE / EA (V / V) = 2/1) to obtain the title compound as a colorless oil (6.8 g, 17 mmol, 67%).
Statistics shows that 2566-44-1 is playing an increasingly important role. we look forward to future research findings about 2-Cyclopropylethanol.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Huang Jianzhou; Ren Qingyun; Xiong Jinfeng; Liu Yang; Yu Fangcai; Liu Weishun; Wang Yifeng; Zhang Yingjun; (104 pag.)CN110903284; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts