As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1,2,4-Butanetriol
A mixture of compound 32 (10.6 g, 100 mmol), compound 7 (10.54 g, 20 mmol) and PTSA (0.1 eq) was heatedunder toluene reflux with Soxhlet extractor containing activated 4A molecular sieves for 3 h. Removal of solvent thencolumn purification (silica gel, 0-30% EtOAc in hexanes) gave compound 33 (11 g, 90 %) as a colorless oil. 1H NMR(400 MHz, CDCl3) delta 5.45 – 5.24 (m, 8H), 4.30 – 4.17 (m, 1H), 4.08 (dd, J = 7.8, 6.1, 1H), 3.80 (dd, J = 10.6, 5.0, 3H),3.53 (t, J = 8.0, 1H), 2.77 (t, J = 6.4, 5H), 2.29 – 2.18 (m, 1H), 2.05 (q, J = 6.7, 9H), 1.86 – 1.74 (m, 2H), 1.59 (dd, J =18.3, 9.7, 5H), 1.42 – 1.18 (m, 43H), 0.89 (t, J = 6.8, 6H). 13C NMR (101 MHz, CDCl3) delta 130.39, 130.36, 130.35, 128.14,112.80, 77.54, 77.22, 76.90, 75.74, 70.14, 61.08, 37.97, 37.50, 35.56, 31.74, 30.14, 30.13, 29.88, 29.80, 29.73, 29.57,29.53, 27.45, 27.41, 25.84, 24.20, 24.00, 22.79, 14.30
With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.
Reference:
Patent; Arbutus Biopharma Corporation; Akinc, Akin; Querbes, William; Wong, Frances; Dorkin, Joseph, Robert; Qin, Xiaojun; Cantley, William; Borodovsky, Anna; De, Soma; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil, G.; (109 pag.)EP3243504; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts