39590-81-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.
Molecular sieves (4 A) and DBU(25 ml, 0.17 mmol) were added to a solution of diol 7a(0.086 g, 0.84 mmol) in DCM (5 ml). The resultingmixture was cooled in an ice bath and trichloracetonitrile(0.34 ml, 3.36 mmol) was added. The reaction was stirredwhile cooling in an ice bath for 4 h until completeconsumtion of the starting material (TLC control, eluentEtOAc-hexane, 1:10). The reaction mixture was filteredthrough a short pad of Celite and the filtrate was evaporated. The residue was purified by flash chromatography onsilica gel column (eluent EtOAc – petroleum ether, 1:20) togive product 1a. Yield 0.270 g (82%). Colorless oil.1H NMR spectrum, delta, ppm: 0.76 (4H, s, CH2CH2); 4.27(4H, s, 2CH2OC(=NH)); 8.25 (2H, s, 2NH). 13C NMRspectrum, delta, ppm: 9.2; 19.7; 72.5; 91.6; 163.1. The productis unstable in the HRMS conditions.
Statistics shows that 39590-81-3 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(Hydroxymethyl)cyclopropane.
Reference:
Article; Skvorcova, Marija; Grigorjeva, Liene; Jirgensons, Aigars; Chemistry of Heterocyclic Compounds; vol. 53; 9; (2017); p. 989 – 996; Khim. Geterotsikl. Soedin.; vol. 53; 9; (2017); p. 989 – 996,8;,
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