Mohammadifarani, Ahmad; Mousavi, Hosna Sadat Zamani; Hosseini, Amin; Aliabadi, Alireza published an article in 2020, the title of the article was Synthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects.Related Products of 621-37-4 And the article contains the following content:
Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ± 0.6 μM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4
The Article related to mercapto triazole phenylacetamide derivative cytotoxicity apoptosis anticancer, Placeholder for records without volume info and other aspects.Related Products of 621-37-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts