Reference of 530-91-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol. A new synthetic method of this compound is introduced below.
Example 292 1,2,3,4-Tetrahydro-2-naphthalenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline (50 mg) was added to toluene (5 ml), and triethylamine (0.5 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (68 mg) in methylene chloride was then added thereto, and the mixture was heated under reflux for 10 min. Next, 1,2,3,4-tetrahydro-2-naphthalenol (34 mg) was added thereto, and the mixture was further stirred with heating under reflux for 3 hr. A saturated aqueous sodium bicarbonate solution was added to stop the reaction, and the reaction solution was then extracted with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution, water, and saturated brine in that order. The extract was dried over sodium sulfate and was then concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (80 mg, yield 100%). 1H-NMR (CDCl3-d1, 400 MHz): delta 2.08 – 2.13 (m, 2H), 2.12 (s, 3H), 2.27 (s, 3H), 2.80 – 3.24 (m, 4H), 4.11 (s, 3H), 4.17 (s, 3H), 5.30 (brs, 1H), 6.43 (s, 1H), 6.57 (d, J = 6.6 Hz, 1H), 6.94 (s, 1H), 7.11 – 7.18 (m, 4H), 7.64 (s, 1H), 7.94 (brs, 1H), 8.15 (d, J = 3.9 Hz, 1H), 8.48 (brs, 1H) Mass spectrometry value (ESI-MS, m/z): 500 (M++1)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,530-91-6, 1,2,3,4-Tetrahydronaphthalen-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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