Synthetic Route of 2968-93-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2968-93-6, name is 2-(4-(Trifluoromethyl)phenyl)ethanol, molecular formula is C9H9F3O, molecular weight is 190.16, as common compound, the synthetic route is as follows.
General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.
Statistics shows that 2968-93-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-(Trifluoromethyl)phenyl)ethanol.
Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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