Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety was written by Xie, Jin;Yang, Fengzhi;Zhang, Man;Lam, Celine;Qiao, Yixue;Xiao, Jia;Zhang, Dongdong;Ge, Yuxuan;Fu, Lei;Xie, Dongsheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.COA of Formula: C9H9F3O This article mentions the following:
A series of caffeic acid phenylethyl ester (CAPE) derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE’s antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50 = 0.4 卤 0.02 & 0.6 卤 0.03 渭M against Hela and DU-145 resp.). In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6COA of Formula: C9H9F3O).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts