Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities was written by Wang, Wang;Xiong, Liangliang;Li, Yutong;Song, Zhuorui;Sun, Dejuan;Li, Hua;Chen, Lixia. And the article was included in Bioorganic & Medicinal Chemistry in 2022.Reference of 111-46-6 This article mentions the following:
As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties I [R = Et, phenyl; R1 = Me, Cl, F, etc], II [R2 = Me, Ph, cyclohexyl, etc.] and III [R3 = Bu, butyne, 1,4-dimethylbenzene, etc.] . Biol. evaluation indicated that compound III [R3 = ethoxyethane] exhibited excellently inhibitory activity on LPS-induced NO production in RAW264.7 cells (IC50 = 0.38 卤 0.18 渭M). The preliminary structure-activity relationships (SARs) suggested that phenylsulfonyl substituted furoxan moiety had the strongest ability to improve anti-inflammatory activity of lathyrane diterpenoids. Furthermore, compound III [R3 = ethoxyethane] significantly reduced the level of ROS. Its mol. mechanism was related to inhibiting the transcriptional activation of Nrf2/HO-1 pathway. Based on these considerations, III [R3 = ethoxyethane] might be a promising anti-inflammatory agent, which is noteworthy for further exploration. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Reference of 111-46-6).
2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 111-46-6
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