Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review was written by Spencer, Ashley;Gazzani, Paul;Thompson, Donna A.. And the article was included in Contact Dermatitis in 2016.Application of 4074-88-8 This article mentions the following:
Summary : Background : (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clin. presentations. Objectives : To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clin. data. Methods : A retrospective review of results from patch tests performed between July 2002 and Sept. 2015, in one tertiary Cutaneous Allergy Unit, was performed Results : A series of 28 (meth)acrylates was applied to 475 patients. Results were pos. in 52 cases, with occupational sources being identified in 24. Industrial exposures and acrylic nails were responsible for 13 and 10 cases, resp., with wound dressings being implicated in 7. We found that four individual (meth)acrylates (2-hydroxyethyl acrylate, 2-hydroxypropyl methacrylate, bisphenol A glycerolate dimethacrylate, and Et acrylate), if used as a screening tool, could have identified 47 (90.4%) of our pos. cases. Conclusions : Our 13-yr experience indicates a changing landscape of (meth)acrylate contact allergy and allergic contact disease, with an observed shift in exposures away from manufacturing and towards acrylic nail sources. Wound dressings are highlighted as emerging sources of sensitization. Larger studies are required to establish the sensitivity and specificity of the four (meth)acrylates proposed for potential screening. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 4074-88-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts