Effects of trapped-into-solids volatile organic compounds on paper biodeteriogens was written by Menicucci, Felicia;Palagano, Eleonora;Michelozzi, Marco;Cencetti, Gabriele;Raio, Aida;Bacchi, Alessia;Mazzeo, Paolo P.;Cuzman, Oana A.;Sidoti, Alessandro;Guarino, Salvatore;Basile, Sara;Riccobono, Ornella;Peri, Ezio;Vizza, Francesco;Ienco, Andrea. And the article was included in International Biodeterioration & Biodegradation in 2022.HPLC of Formula: 499-75-2 This article mentions the following:
Paper items from historical archives and libraries are frequently colonized by biodeteriogens, the management of which is a major concern. Essential oil Volatile Organic Compounds (VOCs) of thymol, carvacrol and eugenol, with high levels of antimicrobial and insect repellent activity, were stabilized within crystalline networks of 尾-cyclodextrins and phenazine-based cocrystals, as a new tool for the control of paper-degrading agents. These formulations were obtained via solvent-free methodologies and resulted as easy handling powders, suitable for the treatment of paper items by indirect contact. Their antimicrobial activity was evaluated on the following species isolated from a book depository at Forte Belvedere (Florence, IT): Alternaria alternata, Aspergillus sp., Cladosporium sp., Trichoderma orientale, Metschnikowia sp., and Bacillus sp. Both formulates displayed a significant antimicrobial activity in vitro, with cocrystals showing higher efficacy than 尾-cyclodextrins. The formulates were also tested against the pest Lasioderma serricorne, towards which the cocrystals entrapping carvacrol and thymol exhibited repellent activity. Overall, the phenazine-carvacrol cocrystal was the best-performing formulate, also giving favorable outcomes in terms of antifungal activity in an on-paper in vitro experiment designed to reproduce on a small-scale the critical conditions of an infested archive. These promising results pave the way towards further experimentations of VOC-based solid formulates, to shed light on such products applicability for the preservation of paper items. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2HPLC of Formula: 499-75-2).
5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 499-75-2
Referemce:
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Alcohols – Chemistry LibreTexts