Tuning Triplet Energy Transfer of Hydroxamates as the Nitrene Precursor for Intramolecular C(sp3)-H Amidation was written by Jung, Hoimin;Keum, Hyeyun;Kweon, Jeonguk;Chang, Sukbok. And the article was included in Journal of the American Chemical Society in 2020.Electric Literature of C9H9F3O This article mentions the following:
Reported herein is the design of a photosensitization strategy to generate triplet nitrenes and its applicability for the intramol. C-H amidation reactions. Substrate optimization by tuning phys. organic parameters according to the proposed energy transfer pathway led us to identify hydroxamates as a convenient nitrene precursor. While more classical nitrene sources, representatively organic azides, were ineffective under the current photosensitization conditions, hydroxamates, which are readily available from alcs. or carboxylic acids, are highly efficient in accessing synthetically valuable 2-oxazolidinones and 纬-lactams by visible light. Mechanism studies supported our working hypothesis that the energy transfer path is mainly operative. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Electric Literature of C9H9F3O).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts