Chemotype of Litsea cubeba Essential Oil and Its Bioactivity was written by Abdul Hammid, Syaliza;Ahmad, Fasihuddin. And the article was included in Natural Product Communications in 2015.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:
The essential oils from different parts of Litsea cubeba, collected from the highlands of Sarawak, were isolated and their chem. compositions analyzed. This study demonstrated significant variations in the chem. compositions and the chem. profiles of the volatiles and could provide valuable supplementary information on the geog. variations of the species. The fruit essential oil was dominated by citronellal, d-limonene and citronellol, while the leaf oil was high in eucalyptol and α-terpineol. High concentrations of citronellal and citronellol in both the root and bark oils were identified. In the stem, the oil was dominated by eucalyptol, d-limonene and α-terpineol. The activity of the oils against brine shrimp larvae, bacteria, yeast and fungi was determined The oils were toxic against brine shrimp larvae with LC50 values ranging from 25.1 – 30.9μL/mL. The oils also demonstrated a wide spectrum of inhibition against microorganisms with inhibition zones between 19.5 – 46.7 mm against Gram-pos. bacteria and 10.5 – 90.0 mm against yeast and fungi. However, the oils were not active against Gram-neg. bacteria. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).
rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts