Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (-)-Suaveoline was written by Tan, Qiuyuan;Yang, Zhao;Jiang, Dan;Cheng, Yuegang;Yang, Jiao;Xi, Song;Zhang, Min. And the article was included in Angewandte Chemie, International Edition in 2019.SDS of cas: 60666-70-8 This article mentions the following:
Based on the discovery of copper-catalyzed cyclopropanol ring-opening addition to iminium ions, an unprecedented catalytic aerobic C-H oxidation/cyclopropanol cyclization cascade using CuCl2 as the multifunctional catalyst and air as the oxidant was developed to construct the azabicyclo[3.3.1]nonane skeleton, which is widespread in natural products and medicines. Using this method, concise asym. total synthesis of the indole alkaloid (-)-suaveoline was achieved. This study not only provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chem. and C-H functionalization. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8SDS of cas: 60666-70-8).
(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60666-70-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts